(JOURN HUMGENETICS) Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon

Wednesday, November 17, 2010

(JOURN HUMGENETICS) Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon

Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon
by: Marc Haber, Daniel E. Platt, Simon Khoury, Danielle A. Badro, Miguel Abboud, Chris Tyler-Smith, Pierre A. Zalloua

Journal of human genetics (28 October 2010)

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Abstract

We have sought to identify signals of assimilation of African male lines in Lebanon by exploring the association of sickle cell disease (SCD) in Lebanon with Y-chromosome haplogroups that are informative of the disease origin and its exclusivity to the Muslim community. A total of 732 samples were analyzed, including 33 SCD patients from Lebanon genotyped for 28 binary markers and 19 short tandem repeats on the non-recombinant segment of the Y chromosome.

Genetic organization was identified using populations known to have influenced the genetic structure of the Lebanese population, in addition to African populations with high incidence of SCD. Y-chromosome haplogroup R-M343 sub-lineages distinguish between sub-Saharan African and Lebanese Y chromosomes.

We detected a limited penetration of SCD into Lebanese R-M343 carriers, restricted to Lebanese Muslims. We suggest that this penetration brought the sickle cell gene along with the African R-M343, probably with the Saharan caravan slave trade.Journal of Human Genetics advance online publication, 28 October 2010; doi:10.1038/jhg.2010.131.

Labels: HEALTHCARE, SICKLE CELL DISEASE